Which matches are you most looking forward to seeing on day eight and who do you think will progress to the quarter-finals from our picks?
Have your say and share with us your predictions by commenting below, using #360fans on Twitter or getting in touch via Facebook.
SERENA WILLIAMS (USA) vs YARASLOVA SHVEDOVA (KAZ)
SERENA (USA) vs SHVEDOVA (KAZ)
- 1 - WORLD RANKING - 52
- 4 - HEAD TO HEAD - 0
- 71 - CAREER TITLES - 1
- 36-5 - 2016 WIN-LOSS - 19-19
Serena takes on the big-serving Kazakh for a place in the quarters.
Serena has lost just three US Open matches since 2008.
She’s back in great form and will likely prove too much to handle.
SPORT360 VERDICT: Serena in two.
SIMONA HALEP (ROUx5) vs SUAREZ NAVARRO (ESPx11)
Share a long history of tight battles, with seven of their 10 encounters going to a final set.
Suarez Navarro won their most recent clash, on clay in Rome 2015, and both are in good form in New York.
Halep is stronger at the majors though.
SPORT360 VERDICT: Halep in three.
VENUS WILLIAMS (USAx6) vs KAROLINA PLISKOVA (CZEx10)
VENUS (USAx6) vs PLISKOVA (CZEx10)
- 6 - WORLD RANKING - 11
- 1 - HEAD TO HEAD - 0
- 49 - CAREER TITLES - 6
- 24-11 - 2016 WIN-LOSS - 36-16
Pliskova’s on an eight-match winning streak and into the second week of a slam for the first time.
She beat three top-10 players en route to the Cincinnati title last month.
Venus is searching for second straight US Open quarter-final.
SPORT360 VERDICT: Pliskova in two.
ANDY MURRAY (GBRx2) vs GRIGOR DIMITROV (BULx22)
Murray lost just three of his last 43 matches.
The reigning Wimbledon and Olympic champion lost his most recent meeting with Dimitrov, during a brief slump in Miami.
Meanwhile, Dimitrov looks like he’s finally past his 2016 woes.
SPORT360 VERDICT: Murray in four.
DOMINIC THIEM (AUTx8) vs JUAN MARTIN DEL POTRO (ARG)
THIEM (AUTx8) vs DEL POTRO (ARG)
- 10 - WORLD RANKING - 142
- 0 - HEAD TO HEAD - 1
- 7 - CAREER TITLES - 18
- 52-16 - 2016 WIN-LOSS - 21-9
Two of the nicest guys on tour face-off, although Del Potro has the tennis world rooting for him during his comeback from wrist surgeries.
Del Potro hasn’t dropped a set yet in New York while Thiem has fought through 12 sets already.
SPORT360 VERDICT: Del Potro in four.