Liam Williams joined Wales' World Cup casualty list after he was ruled out of the rest of the tournament on Sunday with a foot injury.
The 24-year-old Scarlets wing limped off with a foot problem during the second half of Wales' 15-6 Pool A defeat by Australia at Twickenham on Saturday.
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He is the sixth member of Wales' original World Cup squad to be ruled out because of injury following Leigh Halfpenny, Rhys Webb, Scott Williams, Hallam Amos and Cory Allen.
Williams had to overcome a foot injury just to gain a place in coach Warren Gatland's original 31-man squad.
Also capable of playing at full-back, Williams was then concussed during Wales' dramatic 28-25 win over tournament hosts England at Twickenham a fortnight ago and missed the subsequent victory against Fiji.
Liam Williams' injury means Gatland is set to be forced into yet another rejig of his team heading into Wales' World Cup quarter-final against South Africa next weekend.
George North, pushed into centre against Australia, is likely to return to his more familiar wing berth against the two-time world champion Springboks.
That would leave Gatland needing to find a new midfield partner for Jamie Roberts, with utility back James Hook and Tyler Morgan two possible options.
Yet despite all their injury problems, Wales — already qualified for the last eight before Saturday's match — came second in the 'Pool of Death' behind Australia.