Marco Asensio will make his first start of the tournament after Fernando Hierro elected to drop Andres Iniesta for the round-of-16 clash with Russia.
Koke will line up alongside Sergio Busquets in a midfield two while Marco Asensio, Isco and David Silva complement striker Diego Costa – who survives Hierro’s changes despite an indifferent tournament.
Nacho will also start at right-back instead of Dani Carvajal, who had faced a race against time to be fully fit for the World Cup.
Spain: (4-2-3-1): De Gea; Nacho, Pique, Ramos, Alba; Busquets, Koke; D. Silva, Isco, Asensio; Costa.