Visitors condemned Jose Mourinho to his biggest ever home defeat as a manager.
United were in desperate need of a response following a shock defeat at Brighton that led to heightened scrutiny on the manager, key players and background operations.
Mourinho looked to have got the desired response from his players, only for United to unravel in the second half as Harry Kane’s header was complemented by Lucas Moura’s brace as Tottenham ran out 3-0 victors.
“You’re getting sacked in the morning” chanted the visiting fans after Spurs piled the pressure on the Portuguese and ended their run of four successive Old Trafford defeats.
While Mauricio Pochettino’s men enjoy a 100 per cent start to the campaign, this is just the second season in Premier League history that United have lost more than one of their opening three matches – a result few could have imagined during the hosts’ bright start.
Romelu Lukaku should have scored in a first half in which Phil Jones was fortunate not to give away a penalty for a foul on Moura, but the Brazilian would have the last laugh.
Kane’s headed opener was followed up by Moura striking home 133 seconds later, setting up a victory that the Brazilian added gloss to as the clock wound down to ratchet up the pressure on United.