Arsene Wenger handed young defender Konstantinos Mavropanos his Arsenal debut as Henrikh Mkhitaryan came into a much-changed side at former club Manchester United.
David Ospina, Hector Bellerin and Granit Xhaka – the skipper at Old Trafford – were the only players to retain their starting role after Thursday’s Europa League semi-final first-leg 1-1 draw with Atletico Madrid.
Victor Lindelof replaced Phil Jones in United’s only change to the side that beat Tottenham in last week’s FA Cup semi-final.